NPC1L1 as a Pharmacological Target of Hypercholesterolemia
نویسندگان
چکیده
منابع مشابه
NPC1L1: evolution from pharmacological target to physiological sterol transporter.
Niemann-Pick C1-like 1 protein (NPC1L1) was recently shown to be the molecular target of the cholesterol absorption inhibitor class of drugs, of which ezetimibe is the first widely used member. Since its discovery, NPC1L1 has also been shown to play a focal physiological role in intestinal absorption of sterols, including plant sterols and cholesterol. Evidence in support of this new metabolic ...
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ژورنال
عنوان ژورنال: MEMBRANE
سال: 2008
ISSN: 0385-1036,1884-6440
DOI: 10.5360/membrane.33.88